Week 13 Predictions Favor Win Over Titans for the Jacksonville Jaguars

As Week 13 of the NFL season approaches, most analysts and betting markets are leaning toward a Jacksonville Jaguars victory over the Tennessee Titans—a prediction rooted in the Jaguars’ recent momentum, key positional advantages, and the Titans’ ongoing struggles. Both teams enter the game with playoff aspirations in the AFC South, but the Jaguars have emerged as the division’s most consistent performer in recent weeks, while the Titans have faltered with injuries and inconsistent offense. The matchup isn’t just a divisional clash; it’s a chance for the Jaguars to extend their lead in the South and solidify their playoff positioning, while the Titans fight to stay relevant. Week 13 Predictions Favor Win Over Titans for the Jacksonville Jaguars breaks down the core reasons behind the favorable outlook for Jacksonville, from quarterback play to defensive resilience, and why the Titans may struggle to keep up.

A primary driver of the pro-Jaguars predictions is Trevor Lawrence’s recent surge in form, which has turned the Jaguars’ offense into one of the league’s most dynamic units. After a slow start to the season, Lawrence has found his rhythm over the last five games, throwing for 1,324 yards, 11 touchdowns, and just 2 interceptions—including a 368-yard, 3-touchdown performance in Week 12’s win over the Houston Texans. What makes his resurgence even more impactful is his ability to extend plays with his legs: he’s rushed for 123 yards and 2 touchdowns in those five games, keeping defenses off balance. The Titans’ secondary, which ranks 24th in the NFL in passing yards allowed per game (245.6), will struggle to contain Lawrence’s dual-threat ability, especially with star cornerback Kristian Fulton listed as questionable with a hamstring injury. NFL analyst Dan Orlovsky summed up the mismatch: “Lawrence is playing like a top-10 quarterback right now, and the Titans don’t have the personnel to slow him down. He’ll pick apart their zone coverage and make plays when things break down.” This offensive firepower is a big reason predictions tilt toward Jacksonville, as Lawrence has proven he can carry the team in high-stakes games. Week 13 Predictions Favor Win Over Titans for the Jacksonville Jaguars highlights Lawrence’s play as the single biggest factor in the favorable outlook.

Another key reason predictions favor the Jaguars is their dominance in the run game, which aligns perfectly against the Titans’ struggling run defense. The Jaguars rank 7th in the NFL in rushing yards per game (122.8), led by running back Travis Etienne Jr., who has rushed for 894 yards and 5 touchdowns this season with an average of 4.8 yards per carry. Etienne’s speed and elusiveness make him a nightmare for defenses that struggle to contain outside runs—and the Titans’ run defense is exactly that, ranking 22nd in the league and allowing 118.3 rushing yards per game. Adding to Jacksonville’s advantage: their offensive line, which has allowed just 19 sacks all season (10th-best in the NFL), has been dominant in run blocking, creating consistent holes for Etienne. The Titans, meanwhile, have been hit hard by injuries on the defensive line, with starting tackle Jeffery Simmons dealing with a knee injury that limited his snaps in Week 12. Without Simmons’ interior presence, the Titans will struggle to clog running lanes, giving Etienne room to break long gains. Jaguars head coach Doug Pederson has hinted at leaning into the run game in Week 13, saying, “When you have a player like Travis and an O-line that’s blocking like this, you want to use that strength. It sets up the pass and keeps the defense guessing.” This run-game advantage is a critical piece of the prediction puzzle, as it allows the Jaguars to control the clock and limit the Titans’ offensive opportunities. Week 13 Predictions Favor Win Over Titans for the Jacksonville Jaguars explores how this mismatch could dictate the game’s tempo.

For the Jacksonville Jaguars, their defensive ability to neutralize the Titans’ run-heavy offense is another factor boosting predictions in their favor. The Titans have long relied on their rushing attack to drive their offense, but this season, they’ve fallen to 15th in rushing yards per game (112.1) following Derrick Henry’s decline in production. Henry, once the league’s most feared running back, is averaging just 4.1 yards per carry this season—his lowest since 2018—and has been limited by a combination of age (30) and a banged-up offensive line. The Jaguars’ run defense, however, has been stout, ranking 11th in the NFL and allowing just 105.7 rushing yards per game. Led by middle linebacker Foye Oluokun (128 tackles, 2 sacks) and defensive tackle DaVon Hamilton, the Jaguars excel at filling gaps and wrapping up runners quickly, preventing the long gains Henry has historically used to demoralize defenses. In their Week 6 matchup earlier this season, the Jaguars held Henry to 68 yards on 18 carries (3.8 yards per carry) in a 27-17 win. For the Jacksonville Jaguars, neutralizing Henry isn’t just about stopping the run—it’s about forcing the Titans to rely on their passing game, which ranks 29th in the league and features quarterback Ryan Tannehill, who has thrown more interceptions (7) than touchdowns (6) this season. Defensive coordinator Mike Caldwell said, “Our goal is to make them one-dimensional. If we can stop Henry, they’ll have to throw, and that’s where we can capitalize.” This defensive strategy is a major reason analysts believe the Jaguars will win, as it targets the Titans’ biggest strength and turns it into a weakness. Week 13 Predictions Favor Win Over Titans for the Jacksonville Jaguars emphasizes how the Jaguars’ run defense could be the game-changer.

The Jacksonville Jaguars also benefit from a favorable home-field advantage, which has proven crucial in their recent success and factors heavily into Week 13 predictions. TIAA Bank Field in Jacksonville has become a fortress for the Jaguars this season—they’ve gone 5-1 at home, with their only loss coming to the Kansas City Chiefs in a tightly contested 27-24 game. The stadium’s loud, passionate crowd has a history of disrupting opposing offenses, especially the Titans, who have lost four of their last five games in Jacksonville. This season, the Jaguars’ home games have averaged over 67,000 fans, creating a hostile environment that leads to false starts and communication breakdowns for visiting teams. The Titans, who rank 26th in road wins (2-4) this season, have struggled with crowd noise in the past, particularly on offense, where Tannehill has a 76.4 passer rating on the road compared to 89.1 at home. For the Jacksonville Jaguars, the home crowd isn’t just a morale boost—it’s a tactical advantage. Pederson acknowledged this, saying, “Our fans give us an edge. They make it hard for the other team to hear, and that leads to mistakes. We feed off that energy.” With Week 13’s game likely to be a sellout, the crowd will play a key role in keeping the Titans off balance, further strengthening the case for a Jaguars win. Week 13 Predictions Favor Win Over Titans for the Jacksonville Jaguars examines how home-field advantage adds another layer to the favorable prediction.

Finally, the Jaguars’ overall consistency and depth—compared to the Titans’ injury-plagued roster—are why predictions lean so heavily toward Jacksonville in Week 13. The Jaguars have stayed relatively healthy this season, with only a handful of key players missing time, allowing Pederson to maintain a consistent lineup and build chemistry. The Titans, by contrast, have lost 12 players to injured reserve, including starting wide receiver Robert Woods and defensive end Harold Landry III, leaving them thin at critical positions. This depth gap is most evident on offense: the Titans have been forced to rely on unproven backups at wide receiver and offensive line, while the Jaguars have a deep group of playmakers, including Calvin Ridley (55 catches, 708 yards) and Christian Kirk (48 catches, 590 yards), who complement Etienne and Lawrence. The Jaguars also have a more balanced team, ranking 12th in total offense and 14th in total defense, while the Titans rank 22nd in total offense and 18th in total defense. This balance means the Jaguars can win in multiple ways—whether through Lawrence’s passing, Etienne’s running, or a defensive stop—while the Titans are limited to relying on Henry and occasional big plays. NFL insider Adam Schefter noted, “The Jaguars are built to win divisional games like this—they have depth, talent, and a coach who knows how to game-plan for rivals. The Titans, with their injuries, just don’t have the same luxury.” Week 13 Predictions Favor Win Over Titans for the Jacksonville Jaguars concludes that while no NFL game is a sure thing, the Jaguars’ combination of talent, form, and favorable matchups makes them the clear favorite—and a win in Week 13 could be the first step toward securing their first AFC South title since 2017.